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Digital Therapeutics Project, Spring 2023, University of St.Gallen

Fitbits detect lasting changes after Covid-19 (New York Times, 2022), The promise of the metaverse in cardiovascular health (European Heart Journal, 2022), Can Virtual Reality Help Ease Chronic Pain? (The New York Times Magazine, 2022), First of its Kind Alexa Experience Provides Hands-Free Access at Home to General Medical Care (GlobeNewswire, 2022), Can digital technologies improve health? (The Lancet, 2021), Predictive analytics and tailored interventions improve clinical outcomes (npj Digital Medicine, 2021), Q1 2022 Digital Health Funding Reaches $6B Across 183 Deals (Rock Health, 2022).

Digital therapeutics (DTx) use information, sensor, and communication technology to understand, prevent, manage, or treat diseases. The design of these applications requires interdisciplinary expertise at the intersection of medicine, psychology, computer science, technology, management, economics, and law. Only a close collaboration between experts from these disciplines and a specific target population can lead to a shared understanding of the problem at hand and, as a result, highly effective digital health applications. For this reason, national and international students studying computer science, business informatics, psychology, management, economics, or law are invited to work collaboratively with medical students.

DTx and DTx companies have the goal of advancing health care services to fight the ongoing increase of non-communicable diseases (NCDs) and common mental disorders (CMDs) in developed countries. To this end, the question arises of how to develop evidence-based DTx that allow medical doctors and other caregivers to scale and tailor long-term treatments to individuals in need at sustainable costs. Through input lectures and practical applications, this module has, therefore, the objective to help students to understand better the need, design, implementation, and evaluation of DTx.

After the course, students will be able …

  1. to understand the importance of DTx for the prevention, management, and treatment of non-communicable diseases and common mental disorders
  2. to discuss the opportunities and challenges of digital health interventions (e.g., data collection with a mobile DTx)
  3. to gain hands-on experience in the conceptual design, implementation, and evaluation of a mobile DTx

To reach these learning objectives, the following topics are covered:

  1. DTx for the prevention, management, and treatment of NCDs and CMDs
  2. Strategies for long-term compliance with DTx
  3. Conceptual design of a mobile DTx
  4. Technical implementation of a mobile DTx
  5. Evaluation of a smartphone-based DTx

Course Structure

The module consists of live input sessions with interactive group exercises and discussions. Complementary learning material is provided through tutorial video clips, multiple-choice questions, and exercises. Additional coaching sessions are offered to support the groups with the development of their DTx and with the preparation of their presentations. MobileCoach (www.mobile-coach.eu), an open-source DTx design and trial software platform for developing digital biomarkers and health interventions, will be used for the design and evaluation DTx. Programming skills are not required.

In Spring 2023, the following experts in the field bring in these relevant use cases students can work on:

  1. DTx for families coping with delirium, Dr. med. Mathias Schlögl, Barmelweid
  2. DTx for adolescents with diabetes, PD Dr. med. Udo Meinhardt, Facharztpraxis für Endokrinologie, Diabetes & Sportmedizin
  3. DTx for clients of general practitioners “GP 2.0”, Prof. Dr. med. Martin Brutsche, Kantonsspital St.Gallen & Prof. Dr. René Rossi, Empa St.Gallen
  4. DTx for patients preparing for acute interventions, Prof. Dr. med. Hans Rickli & Prof. Dr. med. Miodrag Filipovic, Kantonsspital St.Gallen (to be confirmed)
  5. DTx for remote monitoring of children with asthma, Prof Edgar Delgado-Eckert, University of Basel & Dr. Filipe Barata, ETH Zurich (as part of the Alex project funded by Botnar Research Centre for Child Health)  (to be confirmed)

Course Literature

All relevant learning material will be made available via the online learning platform. Moreover, the content of this module is drawn from the experience of the lecturers and the following work:

  1. Collins LM (2018) Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: The Multiphase Optimization Strategy (MOST), New York: Springer, 10.1007/978-3-319-72206-1
  2. Jacobson N, T Kowatsch & LA Marsch (2022) Digital Therapeutics for Mental Health and Addiction: The State of the Science and Vision for the Future (1st ed.), Cambridge: Elsevier, Academic Press, 978-0-323- 90045-4
  3. Kowatsch T & Fleisch E (2021) Digital Health Interventions, in: Gassmann, O.; Ferrandina, F. (eds): Connected Business, Springer: Cham, 10.1007/978-3-030-76897-3_4
  4. Kowatsch T, L Otto, S Harperink, A Cotti & H Schlieter (2019) A Design and Evaluation Framework for Digital Health Interventions, it- Information Technology 61(5-6), 253-263, 10.1515/itit-2019-0019
  5. Kowatsch T, T Schachner, S Harperink et al. (2021) Conversational Agents as Mediating Social Actors in Chronic Disease Management Involving Health Care Professionals, Patients, and Family Members: Multisite Single-Arm Feasibility Study, Journal of Medical Internet Research (JMIR) 23(2):e25060, 10.2196/25060

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Summary

Digital Therapeutics Project (11,803), University of St.Gallen, Spring 2022, 3 ECTS

  1. HSG Course Information Sheet
  2. MobileCoach Video Tutorials
  3. MobileCoach User Forum
  4. MobileCoach Exercises
Lecturers
Prof. Dr. Tobias Kowatsch
Prof. Dr. Tobias Kowatsch
Professor for Digital Health Interventions, Institute for Implementation Science in Health Care, University of Zurich (UZH); Director, School of Medicine, University of St.Gallen (HSG); Scientific Director, Centre for Digital Health Interventions, UZH, HSG & ETH Zurich, Switzerland
Contact Person
Robert Jakob
Robert JakobMSc Technology and Management (TUM)
Ph.D. candidate and doctoral researcher at the Centre for Digital Health Interventions with a focus on the Prediction and Prevention of Non-Adherence to Digital Health Interventions; Teaching Assistant Digital Health Project Course
Teaching Support
Robert Jakob
Robert JakobMSc Technology and Management (TUM)
Ph.D. candidate and doctoral researcher at the Centre for Digital Health Interventions with a focus on the Prediction and Prevention of Non-Adherence to Digital Health Interventions; Teaching Assistant Digital Health Project Course
Fabian Schneider
Fabian SchneiderB.Sc. in Computer Science
MobileCoach Software Engineer and Community Manager at the Centre for Digital Health Interventions
Prabhakaran Santhanam
Prabhakaran SanthanamM.Sc. in Computer Science
MobileCoach Software Engineer and Community Manager at the Center for Digital Health Interventions