Vinay, R., Uetova, E., Tommila, N., Biller-Andorno, N., Kowatsch, T., GRACE, A Hybrid Rule- and LLM-based Embodied Voice Assistant for Cognitive Stimulation in Older Adults: A Pilot Study Assessing Technical Feasibility, Technology Acceptance, and Working Alliance, JMIR Aging, 10.2196/76489 (forthcoming).

Ulrich, S., Künzli, H., Zuber, V., Kowatsch, T., Gantenbein, A.R., Maintained effectiveness of a smartphone-based chatbot coach (BalanceUP) for mental well-being in headache sufferers: preliminary findings from a single-arm 6-month follow-up study, mHealth 2025;11:49, 10.21037/mhealth-25-9.

Mathews, R.R., Yin, R., Mair, J., Castro, O., Jabir, A., Zheng, S., Tan, S., Kowatsch, T., Müller-Riemenschneider, F., Griva, K., Climate change perceptions, personality traits, and sustainable health behaviours in Singaporean adults, Abstract presented at the Singapore Scientific Conference 2025, 8-11 December 2025, Sands Expo and Convention Centre, Singapore (forthcoming). [PDF]

Mekniran, W., Giger, O.F., Fleisch, E., Kowatsch, T., Jovanova, M., The Longevity Landscape: Mapping Stakeholder Priorities for Healthy Aging among High-Income Countries, BMC Public Health (forthcoming).

Bischof, A., Budig, T., Schläpfer, S., Lukic, Y., Schneider, F., Santhanam, P., Barth, J., Witt, C., Kowatsch, T., Long-term usage of the gamified breathing training Breeze and its effect on momentary relaxation in people with cancer: A cohort study, JMIR Serious Games, 27/10/2025:70297, 10.2196/70297 (forthcoming).

Jovanova, M., Nißen, M.K., Vinay, R., Fleisch, E., von Wangenheim, F., Bucher, T., Piai, G., Bally, L., Brändle, M., Rossi, R.M., Annaheim, S., Defraeye, T., Kowatsch, T., Swiss Precision Digital Therapeutics for the Prevention of Type-2 Diabetes, Annual Meeting SGED-SSED, 13 & 14 November 2025, Proc of Abstracts, No 27, Lucerne, Switzerland, p. 24. [PDF]

Fuchs, M., Wirth, B., Bilz, S., Brändle, M., Kowatsch, T., Jovanova, M., Towards Scalable Digital Studies in Type 2 Diabetes: An Infrastructure for Sensor Integration, Diet Logging, and Customizable Messaging, Annual Meeting SGED-SSED, 13 & 14 November 2025, Proc of Abstracts, No 78, Lucerne, Switzerland, p. 36. [PDF]

Brügger, V., Fuchs, M., Jin, Q., Wirth, B., Bilz, S., Brändle, M., Kowatsch, T., Jovanova, M., Observational Study for Digital Biomarker Development in Prediabetes Screening and Lifestyle Phenotyping: A Study Protocol of the GLOW UP Study, Annual Meeting SGED-SSED, 13 & 14 November 2025, Proc of Abstracts, No 5, Lucerne, Switzerland, p. 18. [PDF]

Mekniran, W., Brügger, V., Fuchs, M., Jin, Q., Wirth, B., Bilz, S., Brändle, M., Kowatsch, T., Jovanova, M., Digital Diabetes Screening in Switzerland: A Cost-effectiveness Analysis, Annual Meeting SGED-SSED, 13 & 14 November 2025, Proc of Abstracts, No 40, Lucerne, Switzerland, p. 27. [PDF]

Giger, O.F., Ackermann, L.J., Principe, M., Meier, S., Fleisch, E., Gallani, S., Brändle, M., Kowatsch, T., Jovanova, M., Advancing Primary Care for Type-2 Diabetes Management: Stakeholder Perspectives on Digital Quality Monitoring in Switzerland, Annual Meeting SGED-SSED, 13 & 14 November 2025, Proc of Abstracts, No 17, Lucerne, Switzerland, p. 21. [PDF]

Jin, Q., Wirth, B., Bilz, S., Brändle, M., Kowatsch, T., Jovanova, M., Performance of Large Language Model-based Nutrition Tracking Services: A Comparative Study of Claude, Gemini, GPT, and AI-Powered Mobile Apps, Annual Meeting SGED-SSED, 13 & 14 November 2025, Proc of Abstracts, No 26, Lucerne, Switzerland, p. 24. [PDF]

Santschi, D., Wilhelm, P., Kowatsch, T., Fehrenbacher, D., How Can Speculative Design Help Anticipate Digital Health Intervention Risks?, Proc. of the International Conference on Information Systems (ICIS) 2025 Conference, Nashville, Tennessee, USA, 14-17 December 2025, IS in Healthcare, Paper 5, aisel.aisnet.org/icis2025/is_health/ishealthcare/5.

Sou, D., Krenböck, S., Gruener, M.R., Bischof, A., Kowatsch, T., Nißen, M., VOGUE: Influence of the menstrual cycle on technology engagement and notification receptivity, 1st Swiss Gender Medicine Symposium 2025, October 20-21, 2025. Bern, Switzerland. Poster presentation. [PDF]

Krohmann, S., Principe, M., Kowatsch, T., Nißen, M., Empowering women across the life course: Extending the open-source menstrual health tracking app CyMe [si:][mi:] for perimenopause, 1st Swiss Gender Medicine Symposium. October 20-21, 2025. Bern, Switzerland. Poster presentation. (forthcoming). [PDF]

Sou, D., Kavassakali, V., Kowatsch, T., Nißen, M., From stigma to support: Fostering menstrual health awareness and literacy in the workplace, Swiss Gender Medicine Symposium 2025, October 20-21, 2025, Bern, Switzerland. Poster presentation. [PDF]

Moser-Chee, L., Senpinar, G., Nißen, M., Enhancing women’s health research through user-centered digital data structures: Preliminary findings from the CyMe [si:][mi:] app researcher needs pilot study, Swiss Gender Medicine Symposium 2025, October 20-21, Bern, Switzerland. Poster presentation. [PDF]

Walliser, F., Biller-Andorno, N., Kowatsch, T., Vinay, R., Evaluating the GRACE voice assistant for dementia care among caregivers and healthcare professionals: An interview study, medRxiv 2025.10.08.25337586, 10.1101/2025.10.08.25337586.

Bitomsky, L., Nißen, M.K., Kowatsch, T., Equity by Design Principles for Digital Health Interventions, International Journal for Equity in Health, 24:271 (2025), 10.1186/s12939-025-02645-6.

Keller, R., Negi, S., Kowatsch, T., von Wangenheim, F., Hui Chua, X., Sim, X., Van Dam, R., Müller-Riemenschneider, F., Edney, S.M., Mair, J., Effects of Cognitive States on Momentary Response Biases in an Ecological Momentary Assessment Study, JMIR Preprints, 10/10/2025:84534 10.2196/preprints.84534.

Weber, S., Deperrois, N., Heun, R., Frühschütz, L., Monn, A., Homan, S., Häfliger, A., Seifritz, E., Kowatsch, T., Kleim, B., Olbrich, S., Using a fine-tuned large language model for symptom-based depression evaluation, npj Digital Medicine 8, 598, 10.1038/s41746-025-01982-8.

Kowatsch, T., Ackermann, L.J., Galliker, H., Lukic, Y., Demonstrating BREEZE-VR: A Gamified Virtual Reality Biofeedback Breathing Training to Strengthen Mental Resilience and Reduce Acute Stress, Mensch und Computer 2025 – Workshopband, Gesellschaft für Informatik e.V., 31. August – 03. September 2025, Chemnitz, Germany, 10.18420/muc2025-mci-demo-330.

Lüscher, J., Pauly, T., Boateng, G., Kowatsch, T., Bodemann, G., Scholz, U., Exploring Dyadic Interactions in Type II Diabetes: Insights from a Naturalistic Observation Study, Abstract presented at the Symposium Unpacking Couples’ Daily Lives: Evidence and Methods for Understanding Close Relationship Dynamics, at the Conference of the Society of Ambulatory Assessment (SAA) 2025, Leuven, Belgium, 26-28 May 2025. [PDF]

Shenoi, A., Li, T., Fleisch, E., Kowatsch, T., Mair, J., LLM-driven Motivational Interviewing for Health Behaviour Change, ISRII 13th Scientific Meeting, University of San Diego, San Diego, California, 4-7 Aug, 2025. [PDF]

Castro, O., Mair, J., Zheng, S., Tan, S., Jabir, A., Yan, X., Chakraborty, B., Tai, E.S., Van Dam, R., von Wangenheim, F., Fleisch, E., Griva, K., Kowatsch, T., Müller-Riemenschneider, F., The LvL UP Trial: Pilot Trial for a Sequential, Multiple Assignment, Randomized Controlled Trial of a Blended Mobile Lifestyle Intervention, 18th International Congress of Behavioral Medicine (ICBM 2025), Vienna, Austria, August 6-9, 2025 .

Zheng, S., Castro, O., Mair, J., Jabir, A., Tan, S., Shenoi, A., Negi, S., Mathews, R.R., Sim Koh, R.W., Yan, X., Chakraborty, B., Tai, E.S., Van Dam, R., von Wangenheim, F., Fleisch, E., Griva, K., Kowatsch, T., Müller-Riemenschneider, F., Pilot Sequential Multiple Assignment Randomised Trial of LvL UP: an Adaptive Holistic mHealth Coaching Intervention Integrating Physical Activity, Diet, and Mental Health, Research Square, 3 September 2025, Preprint, 10.21203/rs.3.rs-7372529/v1.

Vinay, R., Stebler, J.M., Huang, E.M., Kowatsch, T., Towards a Large Language Model Cognitive Storytelling Intervention: Development and Evaluation in a Laboratory Setting, Mensch und Computer 2025 – Workshopband. DOI: 10.18420/muc2025-mci-wip-285. Gesellschaft für Informatik e.V.. MCI: Work in Progress. Chemnitz. 31. August – 03. September 2025, 10.18420/muc2025-mci-wip-285.

Nißen, M., Harperink, S., Joshi, P., Bischof, A., Schachner, T., Lukic, Y., Schneider, F., Santhanam, P., von Wangenheim, F., Ollier, J.B., Kowatsch, T., Leveraging Influencers to Reach and Engage Vulnerable Individuals With a Digital Health Intervention: Quasi-Experimental Field Study, Journal of Medical Internet Research 2025;27:e67174, 10.2196/67174.

Ollier, J.B., Nißen, M., von Wangenheim, F., Rest assured: the influence of chatbots’ assurance statements and service outcome personalization on user data management, Computers in Human Behavior, 10.1016/j.chb.2025.108768.

Tumescheit, C., Sou, D., Nißen, M.K., Kowatsch, T., Hastings, J., Large Language Models Reveal Menstruation Experiences and Needs on Social Media, 20th World Congress on Medical and Health Informatics (MEDINFO), Taipei, 9-13 August 2025, Studies in Health Technology and Informatics, Ebook Volume 329: MEDINFO 2025 — Healthcare Smart × Medicine Deep, 748-752, 10.3233/SHTI250940.

Brill, E., Vinay, R., Nißen, M., Joshi, P., Klöppel, S., Kowatsch, T., Toward a Smartphone-Based and Conversational Agent–Delivered Just-in-Time Adaptive Holistic Lifestyle Intervention for Older Adults Affected by Cognitive Decline: Two-Week Proof-of-Concept Study, JMIR Formative Research, 2025;9:e66885, 10.2196/66885.

Brügger, V., Kowatsch, T., Jovanova, M., Predicting postprandial glucose excursions to personalize dietary interventions for type-2 diabetes management, Scientific Reports, 15, 25920, 10.1038/s41598-025-08003-4.

Brasier, N., Mahato, K., Princip, M., Gonçalves, V.M., Mutyiamana, C., Bourke, S., Goldhahn, J., Barata, F., von Känel, R., Schaffarczyk, D., Kowatsch, T., Wang, J., Next-generation Wearable Sensors for Biopsychosocial Care in Mental Health – a Narrative review, BMJ Digital Health and AI 2025;1:e000018, 10.1136/bmjdhai-2025-000018.

Sou, D., Fuchs, M., Meegahapola, L., Peintner, A., Jutzeler, C.R., Kowatsch, T., Ivanova, O., Nißen, M., How self-tracking and engagement with personalized health content shape self-reported menstrual health experiences in a women’s health app, Research Square, 8 July 2025, Preprint, 10.21203/rs.3.rs-7019879/v1.

Bitomsky, L., Pfitzer, E., Nißen, M.K., Kowatsch, T., Advancing health equity and the role of digital health technologies: a scoping review, BMJ Open 2025;15:e099306, 10.1136/bmjopen-2025-099306.

Giger, O.F., Fleisch, E., Jovanova, M., Kowatsch, T., Barriers and facilitators of implementing value-based care: The case of SwissDiabeter, Digital Health, 11, 10.1177/20552076251336322.

Mair, J., Negi, S., Castro, O., Jabir, A., Shenoi, A., von Wangenheim, F., Kowatsch, T., Using Machine Learning Models to Predict Receptive States for Physical Activity Behavioral Support, Abstract presented at the International Society of Behavioral Nutrition and Physical Activity Conference (ISBNPA), Auckland, New Zealand, June 11-14, 2025, Book of Abstracts. [PDF]

Zheng, S., Castro, O., Mair, J., Tan, X., Jabir, A., Yan, X., Chakraborty, B., Tai, E.S., Van Dam, R., von Wangenheim, F., Fleisch, E., Griva, K., Kowatsch, T., Müller-Riemenschneider, F., Smart Health, Adaptive Support: A Sequential, Multiple Assignment, Randomized Pilot Trial of LvL UP, Abstract presented at the International Society of Behavioral Nutrition and Physical Activity Conference (ISBNPA), Auckland, New Zealand, June 11-14, 2025, Book of Abstracts. [PDF]

Budig, T., Nißen, M.K., Kowatsch, T., Towards the Embodied Conversational Interview Agentic Service ELIAS: Development and Evaluation of a First Prototype, LLM4Good: The 1st Workshop on Sustainable and Trustworthy Large Language Models for Personalization co-located with the 33rd ACM International Conference on User Modeling, Adaptation and Personalization (UMAP 2025), New York, USA, June 16-19, 2025, 10.1145/3708319.3733810.

Brügger, V., Kowatsch, T., Jovanova, M., Using Commercial Wearables for Lifestyle and Metabolic Phenotyping: A Study Protocol of the GLOW UP Study, Abstract presented at the International Society of Behavioral Nutrition and Physical Activity Conference (ISBNPA), Auckland, New Zealand, June 11-14, 2025, Book of Abstracts. [PDF]

Brügger, V., Kowatsch, T., Jovanova, M., Wearables and smartphones for tracking modifiable risk factors in metabolic health: a scoping review, Abstract presented at the International Society of Behavioral Nutrition and Physical Activity Conference (ISBNPA), Auckland, New Zealand, June 11-14, 2025, Book of Abstracts. [PDF]

Fuchs, M., Wirth, B., Bilz, S., Brändle, M., Kowatsch, T., Jovanova, M., Exploring Message Receptivity and Protocol Adherence in a Clinical Study: A Micro-Randomized Trial Protocol, Workshop Envisioning the Future of Interactive Health, co-located with the ACM CHI conference on Human Factors in Computing Systems (CHI 2025), Yokohama, Japan, 26 Apr – 1 May, 2025, 10.5281/zenodo.15203351. [PDF]

Shenoi, A., Teepe, G., Lukic, Y., Negi, S., Mair, J., Fleisch, E., Kowatsch, T., Just Breathe: Harnessing Pretrained Audio Models for Mood Awareness in a Gamified Breathing Training App, Workshop Envisioning the Future of Interactive Health, co-located with the ACM CHI conference on Human Factors in Computing Systems (CHI 2025), Yokohama, Japan, 26 Apr – 1 May, 2025, 10.5281/zenodo.15203351. [PDF]

Mair, J., Jabir, A., Salamanca-Sanabria, A., Castro, O., Zheng, S., Keller, R., Frese, B., Lim, C.S., Alattas, A., Negi, S., Shenoi, A., Van Dam, R., Tai, E.S., Fleisch, E., von Wangenheim, F., Tudor Car, L., Müller-Riemenschneider, F., Kowatsch, T., LvL UP 1.0, a holistic mHealth lifestyle coaching intervention for the prevention of non-communicable diseases and common mental disorders: a mixed methods feasibility study, Research Square Preprint (Version 1, 23 May 2025) 10.21203/rs.3.rs-6484027/v1.

Defraeye, T., Bahrami, F., Kowatsch, T., Annaheim, S., Bragt, M.C.E., Rossi, R.M., Greger, M., Advances in Food-as-Medicine interventions and their impact on future food production, processing, and supply chains, Advances in Nutrition, 16(6), 100421, 10.1016/j.advnut.2025.100421.

Weber, S., Deperrois, N., Heun, R., Frühschütz, L., Monn, A., Homan, S., Häfliger, A., Seifritz, E., Kowatsch, T., Kleim, B., Olbrich, S., Using a Fine-tuned Large Language Model for Symptom-based Depression Evaluation, Research Square Preprint (Version 1, 12 May 2025), 10.21203/rs.3.rs-6555767/v1.

Homan, S., Roman, Z., Ries, A., Santhanam, P., Michel, S., Bertram, A.M., Klee, N., Berther, C., Blaser, S., Gabi, M., Homan, P., Scherer, H., Colla, M., Vetter, S., Olbrich, S., Seifritz, E., Galatzer-Levy, I., Kowatsch, T., Scholz, U., Kleim, B., Subgrouping suicidal ideations:an ecological momentary assessment study in psychiatric inpatients, BMC Psychiatry 25, 469 (2025), 10.1186/s12888-025-06861-w.

Barth, J., Schläpfer, S., Schneider, F., Santhanam, P., Kowatsch, T., Heinz, P., Held, U., Eicher, M., Witt, C., Mobile health intervention CanRelax reduces distress in people with cancer in a randomized controlled trial, npj Digital Medicine 8, 269 (2025), 10.1038/s41746-025-01688-x.

Haug, S., Schaub, M.P., Kowatsch, T., Wirkfaktoren bei mHealth-Anwendungen zum Alkohol- und Tabakkonsum, SuchtMagazin 2/2025, Jg. 51, 5-8, Link.

Vinay, R., Probst, J., Huynh, P., Schlögl, M., Kowatsch, T., Nißen, M., Top-funded digital health companies offering lifestyle interventions for dementia prevention: Company overview and evidence analysis, PLoS One 20(5): e0323390, 10.1371/journal.pone.0323390.

Pfitzer, E., Giger, O.F., Kausch, C., Kowatsch, T., Success Factors and Measures for Scaling Patient-Facing Digital Health Technologies from Leaders Insights, BMC Health Services Research 25(632) 10.1186/s12913-025-12748-z.

Deuber, R., Langer, P., Kraus, M., Pfäffli, M., Bantle, M., Barata, F., von Wangenheim, F., Fleisch, E., Weinmann, W., Wortmann, F., Moving Beyond the Simulator: Interaction-Based Drunk Driving Detection in a Real Vehicle Using Driver Monitoring Cameras and Real-Time Vehicle Data, In Proceedings of the 2025 CHI Conference on Human Factors in Computing Systems (CHI ’25). Association for Computing Machinery, New York, NY, USA, Article 84, 1–25. 10.1145/3706598.3714007 ***Best Paper***.

Vinay, R., Spitale, G., Biller-Andorno, N., Germani, F., Emotional prompting amplifies disinformation generation in AI large language models, Frontiers in Artificial Intelligence, 8:1543603, 10.3389/frai.2025.1543603.

Mair, J., Hashim, J., Linh, T.M., Tai, E.S., Ryan, J., Kowatsch, T., Müller-Riemenschneider, F., Edney, S.M., Understanding and Overcoming Barriers to Digital Health Adoption: A Patient and Public Involvement Study, Translational Behavioral Medicine, 15(1), ibaf010, 10.1093/tbm/ibaf010 .

Gruener, M.R., West, E., Muhitira, U., Heldt, K., Oberhauser, S., l’Allemand, D., Jovanova, M., Kowatsch, T., Broser, P.J., Assessing Glucose Variability Metrics: Nerve Conduction Velocity in Children and Adolescents with Type 1 Diabetes, medRxiv 2025.03.25.25324553, 10.1101/2025.03.25.25324553.

Castro, O., Norris, E., Wright, A.J., Hayes, E., Howes, E., Moore, C., West, R., Michie, S., Creating a body of physical activity evidence to test the generalisation of annotation methods for automated evidence synthesis, Abstract presented 9th International Conference from the UCL Centre for Behaviour Change, Lisbon, Portugal, 2-3 April 2025. [PDF]

Castro, O., Fajardo, G., Johnston, M., Laroze, D., Leiva-Pinto, E., Figueroa, O., Corker, E., Chacón-Candia, J., Duarte, G., Translating the behaviour change technique taxonomy version 1 into Spanish: Methodology and validation, Abstract presented at the Digital Health Session, The Society of Behavioral Medicine’s 46th Annual Meeting & Scientific Sessions, San Francisco, CA, March 26 – 29, 2025. [PDF]

Mair, J., Edney, S.M., Hashim, J., Müller-Riemenschneider, F., Tai, E.S., Ryan, J., Kowatsch, T., Behavioral Mechanisms Driving the Uptake and Sustained Use of Digital Health Interventions in a Multicultural Population, Abstract presented at the Digital Health Session, The Society of Behavioral Medicine’s 46th Annual Meeting & Scientific Sessions, San Francisco, CA, March 26 – 29, 2025. [PDF]

Huynh, P., Stöckli, S., Fleisch, E., Kowatsch, T., Vinay, R., Technological integration and business models of leading home care providers for older adults: A systematic market analysis and multiple case study, Abstract presented at the 11th Asian Conference on Aging & Gerontology (AGen2025), Tokyo, Japan, 24-29 March 2025. [PDF]

Huynh, P., Kowatsch, T., Stöckli, S., Vinay, R., Leveraging technology to transform home care for older adults: Challenges, innovations, and implications, Abstract presented at the 11th Asian Conference on Aging & Gerontology (AGen2025), Tokyo, Japan, 24-29 March 2025. [PDF]

Mekniran, W., Kowatsch, T., EDEN: Towards a Computational Framework to Align Incentives in Healthy Aging, In Proc of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies – Volume 2: HEALTHINF, ISBN 978-989-758-731-3, ISSN 2184-4305, 1067-1076, 10.5220/0013359800003911. [PDF]

Pfitzer, E., Kowatsch, T., Challenges and Innovations in Digitizing Elderly Care in Switzerland: A Single Case Study, In Proc of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies – Volume 2: HEALTHINF, ISBN 978-989-758-731-3, ISSN 2184-4305, 1077-1082, 10.5220/0013395400003911. [PDF]

Huynh, P., Adoption and Challenges of Digital Technologies in Home Care for Older Adults in Austria: Bridging Practical and Managerial Perspectives, In Proc of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies – Volume 2: HEALTHINF, ISBN 978-989-758-731-3, ISSN 2184-4305, 1057-1066, 10.5220/0013307700003911. [PDF]

Nißen, M., Prinz, S., Beyond Safety: Towards Non-Stigmatizing Mobile Emergency Watches that Empower Older Adults, In Proc of the 18th International Joint Conference on Biomedical Engineering Systems and Technologies – Volume 2: HEALTHINF, ISBN 978-989-758-731-3, ISSN 2184-4305, 1092-1098, 10.5220/0013399800003911. [PDF]

Castro, O., Mair, J., Zheng, S., Tan, S., Jabir, A., Yan, X., Chakraborty, B., Tai, E.S., Van Dam, R., von Wangenheim, F., Fleisch, E., Griva, K., Kowatsch, T., Müller-Riemenschneider, F., The LvL UP Trial: Protocol for a Sequential, Multiple Assignment, Randomized Controlled Trial to Assess the Effectiveness of a Blended Mobile Lifestyle Intervention, Contemporary Clinical Trials, 10.1016/j.cct.2025.107833.

Paersch, C., Recher, D.A., Schulz, A., Heininger, M., Schlup, B., Künzler, F., Homan, S., Kowatsch, T., Fisher, A.J., Horn, A., Kleim, B., Self-Efficacy Effects on Symptom Experiences in Daily Life and Early Treatment Success in Anxiety Patients, Clinical Psychological Science, 13(1), 178-194, 10.1177/21677026231205262.